Frequent Aneuploidy in Primary Human T Cells after CRISPR-Cas9 cleavage

Multiple clinical trials of allogeneic T cell therapy use site-specific nucleases to disrupt T cell receptor (TCR) and other genes (1–6). Here, using single-cell RNA sequencing, we investigated genome editing outcomes in primary human T cells transfected with CRISPR-Cas9 and guide RNAs targeting gen...

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Detalles Bibliográficos
Autores principales: Nahmad, A.D., Reuveni, E., Goldschmidt, E., Tenne, T., Liberman, M., Horovitz-Fried, M., Khosravi, R., Kobo, H., Reinstein, E., Madi, A., Ben-David, U., Barzel, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7613940/
https://www.ncbi.nlm.nih.gov/pubmed/35773341
http://dx.doi.org/10.1038/s41587-022-01377-0

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