Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape

Statistical mechanics can describe the major conformational ensembles determining the equilibrium free-energy landscape of a folding protein. The challenge is to capture the full repertoire of low-occurrence conformations separated by high kinetic barriers that define complex landscapes. Computation...

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Detalles Bibliográficos
Autores principales: Tapia-Rojo, Rafael, Mora, Marc, Board, Stephanie, Walker, Jane, Boujemaa-Paterski, Rajaa, Medalia, Ohad, Garcia-Manyes, Sergi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614079/
https://www.ncbi.nlm.nih.gov/pubmed/36660164
http://dx.doi.org/10.1038/s41567-022-01808-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614079/
https://www.ncbi.nlm.nih.gov/pubmed/36660164
http://dx.doi.org/10.1038/s41567-022-01808-4

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