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Enhanced statistical sampling reveals microscopic complexity in the talin mechanosensor folding energy landscape
Statistical mechanics can describe the major conformational ensembles determining the equilibrium free-energy landscape of a folding protein. The challenge is to capture the full repertoire of low-occurrence conformations separated by high kinetic barriers that define complex landscapes. Computation...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614079/ https://www.ncbi.nlm.nih.gov/pubmed/36660164 http://dx.doi.org/10.1038/s41567-022-01808-4 |