Polyamine pathway activity promotes cysteine essentiality in cancer cells

Cancer cells have high demands for non-essential amino acids (NEAA), which are precursors for anabolic and anti-oxidant pathways supporting cell survival and proliferation. It is well established that cancer cells consume the NEAA cysteine, and that cysteine deprivation can induce cell death, howeve...

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Detalles Bibliográficos
Autores principales: Zhang, Tong, Bauer, Christin, Newman, Alice C., Uribe, Alejandro Huerta, Athineos, Dimitris, Blyth, Karen, Maddocks, Oliver D.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614128/
https://www.ncbi.nlm.nih.gov/pubmed/32747794
http://dx.doi.org/10.1038/s42255-020-0253-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614128/
https://www.ncbi.nlm.nih.gov/pubmed/32747794
http://dx.doi.org/10.1038/s42255-020-0253-2

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