Making the leap from structure to mechanism: are the open states of mammalian complex I identified by cryoEM resting states or catalytic intermediates?

Respiratory complex I (NADH:ubiquinone oxidoreductase) is a multi-subunit, energy-transducing mitochondrial enzyme that is essential for oxidative phosphorylation and regulating NAD(+)/NADH pools. Despite recent advances in structural knowledge and a long history of biochemical analyses, the mechani...

Descripción completa

Detalles Bibliográficos
Autores principales: Chung, Injae, Grba, Daniel N., Wright, John J., Hirst, Judy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614202/
https://www.ncbi.nlm.nih.gov/pubmed/36087446
http://dx.doi.org/10.1016/j.sbi.2022.102447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614202/
https://www.ncbi.nlm.nih.gov/pubmed/36087446
http://dx.doi.org/10.1016/j.sbi.2022.102447

Ejemplares similares