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Making the leap from structure to mechanism: are the open states of mammalian complex I identified by cryoEM resting states or catalytic intermediates?
Respiratory complex I (NADH:ubiquinone oxidoreductase) is a multi-subunit, energy-transducing mitochondrial enzyme that is essential for oxidative phosphorylation and regulating NAD(+)/NADH pools. Despite recent advances in structural knowledge and a long history of biochemical analyses, the mechani...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614202/ https://www.ncbi.nlm.nih.gov/pubmed/36087446 http://dx.doi.org/10.1016/j.sbi.2022.102447 |