Structural Basis of Mammalian Respiratory Complex I Inhibition by Medicinal Biguanides

The molecular mode of action of metformin, a biguanide used widely in the treatment of diabetes, is incompletely characterized. Here we define the inhibitory drug-target interaction(s) of a model biguanide with mammalian respiratory complex I by combining cryo-electron microscopy and enzyme kinetics...

Descripción completa

Detalles Bibliográficos
Autores principales: Bridges, Hannah R., Blaza, James N., Yin, Zhan, Chung, Injae, Pollak, Michael N., Hirst, Judy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614227/
https://www.ncbi.nlm.nih.gov/pubmed/36701435
http://dx.doi.org/10.1126/science.ade3332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614227/
https://www.ncbi.nlm.nih.gov/pubmed/36701435
http://dx.doi.org/10.1126/science.ade3332

Ejemplares similares