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Structural Basis of Mammalian Respiratory Complex I Inhibition by Medicinal Biguanides

The molecular mode of action of metformin, a biguanide used widely in the treatment of diabetes, is incompletely characterized. Here we define the inhibitory drug-target interaction(s) of a model biguanide with mammalian respiratory complex I by combining cryo-electron microscopy and enzyme kinetics...

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Detalles Bibliográficos
Autores principales:	Bridges, Hannah R., Blaza, James N., Yin, Zhan, Chung, Injae, Pollak, Michael N., Hirst, Judy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614227/ https://www.ncbi.nlm.nih.gov/pubmed/36701435 http://dx.doi.org/10.1126/science.ade3332

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