STAT1 is essential for HSC function and maintains MHCII(hi) stem cells that resist myeloablation and neoplastic expansion

Adult hematopoietic stem cells (HSCs) are predominantly quiescent and can be activated in response to acute stress such as infection or cytotoxic insults. STAT1 is a pivotal downstream mediator of interferon (IFN) signaling and is required for IFN-induced HSC proliferation, but little is known about...

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Detalles Bibliográficos
Autores principales: Li, Juan, Williams, Matthew J., Park, Hyun Jung, Bastos, Hugo P., Wang, Xiaonan, Prins, Daniel, Wilson, Nicola K., Johnson, Carys, Sham, Kendig, Wantoch, Michelle, Watcham, Sam, Kinston, Sarah J., Pask, Dean C., Hamilton, Tina L., Sneade, Rachel, Waller, Amie K., Ghevaert, Cedric, Vassiliou, George S., Laurenti, Elisa, Kent, David G., Göttgens, Berthold, Green, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614316/
https://www.ncbi.nlm.nih.gov/pubmed/35767701
http://dx.doi.org/10.1182/blood.2021014009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614316/
https://www.ncbi.nlm.nih.gov/pubmed/35767701
http://dx.doi.org/10.1182/blood.2021014009

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