Single-cell fate mapping reveals widespread clonal ignorance of low-affinity T cells exposed to systemic infection

T cell ignorance is a specific form of immunological tolerance. It describes the maintenance of naivety in antigen-specific T cells in vivo despite the presence of their target antigen. It is thought to mainly play a role during the steady state, when self-antigens are presented in absence of costim...

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Detalles Bibliográficos
Autores principales: Leube, Justin, Mühlbauer, Anton, Andrä, Immanuel, Biggel, Madleen, Busch, Dirk H., Kretschmer, Lorenz, Buchholz, Veit R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614329/
https://www.ncbi.nlm.nih.gov/pubmed/36458456
http://dx.doi.org/10.1002/eji.202250009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614329/
https://www.ncbi.nlm.nih.gov/pubmed/36458456
http://dx.doi.org/10.1002/eji.202250009

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