CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis

Human cells license tens of thousands of origins of replication in G1 and then must stop all licensing before DNA synthesis in S phase to prevent re-replication and genome instability that ensue when an origin is licensed on replicated DNA. However, the E3 ubiquitin ligase CRL4(Cdt2) only starts to...

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Detalles Bibliográficos
Autores principales: Ratnayeke, Nalin, Baris, Yasemin, Chung, Mingyu, Yeeles, Joseph T.P., Meyer, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614657/
https://www.ncbi.nlm.nih.gov/pubmed/36608667
http://dx.doi.org/10.1016/j.molcel.2022.12.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614657/
https://www.ncbi.nlm.nih.gov/pubmed/36608667
http://dx.doi.org/10.1016/j.molcel.2022.12.004

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