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CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
Human cells license tens of thousands of origins of replication in G1 and then must stop all licensing before DNA synthesis in S phase to prevent re-replication and genome instability that ensue when an origin is licensed on replicated DNA. However, the E3 ubiquitin ligase CRL4(Cdt2) only starts to...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614657/ https://www.ncbi.nlm.nih.gov/pubmed/36608667 http://dx.doi.org/10.1016/j.molcel.2022.12.004 |