Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network

Germinal centers (GCs) require sustained availability of antigens to promote antibody affinity maturation against pathogens and vaccines. A key source of antigens for GC B cells are immune complexes (ICs) displayed on follicular dendritic cells (FDCs). Here we show that FDC spatial organization regu...

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Detalles Bibliográficos
Autores principales: Martínez-Riaño, Ana, Wang, Shenshen, Boeing, Stefan, Minoughan, Sophie, Casal, Antonio, Spillane, Katelyn M, Ludewig, Burkhard, Tolar, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614842/
https://www.ncbi.nlm.nih.gov/pubmed/37443283
http://dx.doi.org/10.1038/s41590-023-01559-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614842/
https://www.ncbi.nlm.nih.gov/pubmed/37443283
http://dx.doi.org/10.1038/s41590-023-01559-1

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