Cargando…
Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network
Germinal centers (GCs) require sustained availability of antigens to promote antibody affinity maturation against pathogens and vaccines. A key source of antigens for GC B cells are immune complexes (ICs) displayed on follicular dendritic cells (FDCs). Here we show that FDC spatial organization regu...
Autores principales: | Martínez-Riaño, Ana, Wang, Shenshen, Boeing, Stefan, Minoughan, Sophie, Casal, Antonio, Spillane, Katelyn M, Ludewig, Burkhard, Tolar, Pavel |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614842/ https://www.ncbi.nlm.nih.gov/pubmed/37443283 http://dx.doi.org/10.1038/s41590-023-01559-1 |
Ejemplares similares
-
Germinal center B cells recognize antigen through a specialized immune synapse architecture
por: Nowosad, Carla R., et al.
Publicado: (2016) -
Remodeling of light and dark zone follicular dendritic cells governs germinal center responses
por: Pikor, Natalia B, et al.
Publicado: (2020) -
Follicular dendritic cells help establish follicle identity and promote B cell retention in germinal centers
por: Wang, Xiaoming, et al.
Publicado: (2011) -
B cell antigen extraction is regulated by physical properties of antigen-presenting cells
por: Spillane, Katelyn M., et al.
Publicado: (2017) -
T follicular regulatory cells: Guardians of the germinal centre?
por: Fahlquist Hagert, Cecilia, et al.
Publicado: (2020)