Suppression of innate immunity by the vaccinia virus protein N1 promotes skin microbiota expansion and increased immune infiltration following vaccination

Vaccinia virus (VACV) protein N1 is an intracellular immunomodulator that contributes to virus virulence via inhibition of NF-κB. Intradermal infection with a VACV lacking gene N1L (vΔN1) results in smaller skin lesions than infection with wild-type virus (WT VACV), but the impact of N1 deletion on...

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Detalles Bibliográficos
Autores principales: Shmeleva, Evgeniya V., Syafiq, Danial, Moldoveanu, Ana L., Ferguson, Brian J., Smith, Geoffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614846/
https://www.ncbi.nlm.nih.gov/pubmed/36748513
http://dx.doi.org/10.1099/jgv.0.001814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614846/
https://www.ncbi.nlm.nih.gov/pubmed/36748513
http://dx.doi.org/10.1099/jgv.0.001814

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