Synthetic lethal approaches to target cancers with loss of PTEN function

Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP(3)) into phosphatidylinositol 4,5-bisphosphate (PIP(2)). The function of PTEN is regulated by different...

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Detalles Bibliográficos
Autores principales: Ertay, Ayse, Ewing, Rob M., Wang, Yihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614861/
https://www.ncbi.nlm.nih.gov/pubmed/37533462
http://dx.doi.org/10.1016/j.gendis.2022.12.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614861/
https://www.ncbi.nlm.nih.gov/pubmed/37533462
http://dx.doi.org/10.1016/j.gendis.2022.12.015

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