YAP/TAZ as master regulators in cancer – modulation, function and therapeutic approaches

Our understanding of the function of the transcriptional regulators YAP/TAZ in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction, and highlight open questions. YAP/TAZ signaling is an addiction...

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Detalles Bibliográficos
Autores principales: Piccolo, Stefano, Panciera, Tito, Contessotto, Paolo, Cordenonsi, Michelangelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614914/
https://www.ncbi.nlm.nih.gov/pubmed/36564601
http://dx.doi.org/10.1038/s43018-022-00473-z
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author Piccolo, Stefano
Panciera, Tito
Contessotto, Paolo
Cordenonsi, Michelangelo
author_facet Piccolo, Stefano
Panciera, Tito
Contessotto, Paolo
Cordenonsi, Michelangelo
author_sort Piccolo, Stefano
collection PubMed
description Our understanding of the function of the transcriptional regulators YAP/TAZ in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction, and highlight open questions. YAP/TAZ signaling is an addiction shared by multiple tumor types and their microenvironments, providing many malignant attributes. As such, it represents an important vulnerability that may offer a broad window of therapeutic efficacy, and here we give an overview of the current treatment strategies and pioneering clinical trials.
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spelling pubmed-76149142023-08-09 YAP/TAZ as master regulators in cancer – modulation, function and therapeutic approaches Piccolo, Stefano Panciera, Tito Contessotto, Paolo Cordenonsi, Michelangelo Nat Cancer Article Our understanding of the function of the transcriptional regulators YAP/TAZ in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction, and highlight open questions. YAP/TAZ signaling is an addiction shared by multiple tumor types and their microenvironments, providing many malignant attributes. As such, it represents an important vulnerability that may offer a broad window of therapeutic efficacy, and here we give an overview of the current treatment strategies and pioneering clinical trials. 2023-01 2022-12-23 /pmc/articles/PMC7614914/ /pubmed/36564601 http://dx.doi.org/10.1038/s43018-022-00473-z Text en https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
spellingShingle Article
Piccolo, Stefano
Panciera, Tito
Contessotto, Paolo
Cordenonsi, Michelangelo
YAP/TAZ as master regulators in cancer – modulation, function and therapeutic approaches
title YAP/TAZ as master regulators in cancer – modulation, function and therapeutic approaches
title_full YAP/TAZ as master regulators in cancer – modulation, function and therapeutic approaches
title_fullStr YAP/TAZ as master regulators in cancer – modulation, function and therapeutic approaches
title_full_unstemmed YAP/TAZ as master regulators in cancer – modulation, function and therapeutic approaches
title_short YAP/TAZ as master regulators in cancer – modulation, function and therapeutic approaches
title_sort yap/taz as master regulators in cancer – modulation, function and therapeutic approaches
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614914/
https://www.ncbi.nlm.nih.gov/pubmed/36564601
http://dx.doi.org/10.1038/s43018-022-00473-z
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