RNA recording in single bacterial cells using reprogrammed tracrRNAs

Capturing an individual cell’s transcriptional history is a challenge exacerbated by the functional heterogeneity of cellular communities. Here, we leverage reprogrammed tracrRNAs (Rptrs) to record selected cellular transcripts as stored DNA edits in single living bacterial cells. Rptrs are designed...

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Detalles Bibliográficos
Autores principales: Jiao, Chunlei, Reckstadt, Claas, König, Fabian, Homberger, Christina, Yu, Jiaqi, Vogel, Jörg, Westermann, Alexander J., Sharma, Cynthia M., Beisel, Chase L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614944/
https://www.ncbi.nlm.nih.gov/pubmed/36604543
http://dx.doi.org/10.1038/s41587-022-01604-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614944/
https://www.ncbi.nlm.nih.gov/pubmed/36604543
http://dx.doi.org/10.1038/s41587-022-01604-8

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