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Polycystic kidney disease: The cilia mechanosensation debate gets (bio)physical

For the first time, two new studies applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated that force-based bending of a single nodal axoneme is sufficient to induce intraciliary Ca(2+) flux in a PKD2-dependent manner, which propagated to drive asymmet...

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Detalles Bibliográficos
Autores principales: Wachten, Dagmar, Mill, Pleasantine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614964/
https://www.ncbi.nlm.nih.gov/pubmed/36914889
http://dx.doi.org/10.1038/s41581-023-00701-4