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Polycystic kidney disease: The cilia mechanosensation debate gets (bio)physical
For the first time, two new studies applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated that force-based bending of a single nodal axoneme is sufficient to induce intraciliary Ca(2+) flux in a PKD2-dependent manner, which propagated to drive asymmet...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614964/ https://www.ncbi.nlm.nih.gov/pubmed/36914889 http://dx.doi.org/10.1038/s41581-023-00701-4 |
| Sumario: | For the first time, two new studies applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated that force-based bending of a single nodal axoneme is sufficient to induce intraciliary Ca(2+) flux in a PKD2-dependent manner, which propagated to drive asymmetric gene expression. |
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