Polycystic kidney disease: The cilia mechanosensation debate gets (bio)physical

For the first time, two new studies applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated that force-based bending of a single nodal axoneme is sufficient to induce intraciliary Ca(2+) flux in a PKD2-dependent manner, which propagated to drive asymmet...

Descripción completa

Detalles Bibliográficos
Autores principales: Wachten, Dagmar, Mill, Pleasantine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614964/
https://www.ncbi.nlm.nih.gov/pubmed/36914889
http://dx.doi.org/10.1038/s41581-023-00701-4
_version_ 1783605676109463552
author Wachten, Dagmar
Mill, Pleasantine
author_facet Wachten, Dagmar
Mill, Pleasantine
author_sort Wachten, Dagmar
collection PubMed
description For the first time, two new studies applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated that force-based bending of a single nodal axoneme is sufficient to induce intraciliary Ca(2+) flux in a PKD2-dependent manner, which propagated to drive asymmetric gene expression.
format Online
Article
Text
id pubmed-7614964
institution National Center for Biotechnology Information
language English
publishDate 2023
record_format MEDLINE/PubMed
spelling pubmed-76149642023-08-18 Polycystic kidney disease: The cilia mechanosensation debate gets (bio)physical Wachten, Dagmar Mill, Pleasantine Nat Rev Nephrol Article For the first time, two new studies applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated that force-based bending of a single nodal axoneme is sufficient to induce intraciliary Ca(2+) flux in a PKD2-dependent manner, which propagated to drive asymmetric gene expression. 2023-05-01 /pmc/articles/PMC7614964/ /pubmed/36914889 http://dx.doi.org/10.1038/s41581-023-00701-4 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
spellingShingle Article
Wachten, Dagmar
Mill, Pleasantine
Polycystic kidney disease: The cilia mechanosensation debate gets (bio)physical
title Polycystic kidney disease: The cilia mechanosensation debate gets (bio)physical
title_full Polycystic kidney disease: The cilia mechanosensation debate gets (bio)physical
title_fullStr Polycystic kidney disease: The cilia mechanosensation debate gets (bio)physical
title_full_unstemmed Polycystic kidney disease: The cilia mechanosensation debate gets (bio)physical
title_short Polycystic kidney disease: The cilia mechanosensation debate gets (bio)physical
title_sort polycystic kidney disease: the cilia mechanosensation debate gets (bio)physical
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614964/
https://www.ncbi.nlm.nih.gov/pubmed/36914889
http://dx.doi.org/10.1038/s41581-023-00701-4
work_keys_str_mv AT wachtendagmar polycystickidneydiseasetheciliamechanosensationdebategetsbiophysical
AT millpleasantine polycystickidneydiseasetheciliamechanosensationdebategetsbiophysical

Ejemplares similares