The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes

How the opportunistic Gram-negative pathogens of the genus Achromobacter interact with the innate immune system is poorly understood. Using three Achromobacter clinical isolates from two species, we show that the type 3 secretion system (T3SS) is required to induce cell death in human macrophages by...

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Detalles Bibliográficos
Autores principales: Turton, Keren, Parks, Hannah J., Zarodkiewicz, Paulina, Hamad, Mohamad A., Dwane, Rachel, Parau, Georgiana, Ingram, Rebecca J., Coll, Rebecca C., Bryant, Clare E., Valvano, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614980/
https://www.ncbi.nlm.nih.gov/pubmed/37598340
http://dx.doi.org/10.1016/j.celrep.2023.113012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614980/
https://www.ncbi.nlm.nih.gov/pubmed/37598340
http://dx.doi.org/10.1016/j.celrep.2023.113012

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