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DNMT3A binds ubiquitinated histones to regulate bivalent genes
A new study demonstrates that the disordered N-terminal domain of DNMT3A1 binds PRC1-catalyzed H2AK119ub, targeting DNA methylation to bivalent promoters in mouse brain cortical cells. Methylation around bivalent genes is critical for mouse postnatal development, and could be equally important in ot...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615034/ https://www.ncbi.nlm.nih.gov/pubmed/35534560 http://dx.doi.org/10.1038/s41588-022-01073-4 |