DNMT3A binds ubiquitinated histones to regulate bivalent genes

A new study demonstrates that the disordered N-terminal domain of DNMT3A1 binds PRC1-catalyzed H2AK119ub, targeting DNA methylation to bivalent promoters in mouse brain cortical cells. Methylation around bivalent genes is critical for mouse postnatal development, and could be equally important in ot...

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Detalles Bibliográficos
Autores principales: Parry, Aled J., Reik, Wolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615034/
https://www.ncbi.nlm.nih.gov/pubmed/35534560
http://dx.doi.org/10.1038/s41588-022-01073-4
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author Parry, Aled J.
Reik, Wolf
author_facet Parry, Aled J.
Reik, Wolf
author_sort Parry, Aled J.
collection PubMed
description A new study demonstrates that the disordered N-terminal domain of DNMT3A1 binds PRC1-catalyzed H2AK119ub, targeting DNA methylation to bivalent promoters in mouse brain cortical cells. Methylation around bivalent genes is critical for mouse postnatal development, and could be equally important in other cell types and in disease.
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spelling pubmed-76150342023-09-08 DNMT3A binds ubiquitinated histones to regulate bivalent genes Parry, Aled J. Reik, Wolf Nat Genet Article A new study demonstrates that the disordered N-terminal domain of DNMT3A1 binds PRC1-catalyzed H2AK119ub, targeting DNA methylation to bivalent promoters in mouse brain cortical cells. Methylation around bivalent genes is critical for mouse postnatal development, and could be equally important in other cell types and in disease. 2022-05-01 /pmc/articles/PMC7615034/ /pubmed/35534560 http://dx.doi.org/10.1038/s41588-022-01073-4 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
spellingShingle Article
Parry, Aled J.
Reik, Wolf
DNMT3A binds ubiquitinated histones to regulate bivalent genes
title DNMT3A binds ubiquitinated histones to regulate bivalent genes
title_full DNMT3A binds ubiquitinated histones to regulate bivalent genes
title_fullStr DNMT3A binds ubiquitinated histones to regulate bivalent genes
title_full_unstemmed DNMT3A binds ubiquitinated histones to regulate bivalent genes
title_short DNMT3A binds ubiquitinated histones to regulate bivalent genes
title_sort dnmt3a binds ubiquitinated histones to regulate bivalent genes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615034/
https://www.ncbi.nlm.nih.gov/pubmed/35534560
http://dx.doi.org/10.1038/s41588-022-01073-4
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