Using genetics to examine the overall and sex-specific associations of branch-chain amino acids and the valine metabolite, 3-hydroxyisobutyrate, with ischemic heart disease and diabetes: a two-sample Mendelian randomization study

BACKGROUND AND AIMS: Branch-chain amino acids (BCAAs) are linked to higher risk of diabetes, whilst the evidence on ischemic heart disease (IHD) is limited. Valine metabolite, 3-hydroxyisobutyrate (3-HIB), also plays an important role in metabolism, whilst its effect has been rarely examined. At the...

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Detalles Bibliográficos
Autores principales: Zhao, Jie V, Fan, Bohan, Burgess, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615055/
https://www.ncbi.nlm.nih.gov/pubmed/37660674
http://dx.doi.org/10.1016/j.atherosclerosis.2023.117246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615055/
https://www.ncbi.nlm.nih.gov/pubmed/37660674
http://dx.doi.org/10.1016/j.atherosclerosis.2023.117246

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