Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4-NOT

Translation impacts mRNA stability and, in yeast, this is mediated by the Ccr4-Not deadenylation complex. The details of this process in mammals remain unclear. Here, we use cryoEM and crosslinking mass spectrometry to show that mammalian CCR4-NOT specifically recognizes ribosomes that are stalled d...

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Detalles Bibliográficos
Autores principales: Absmeier, Eva, Chandrasekaran, Viswanathan, O’Reilly, Francis J, Stowell, James AW, Rappsilber, Juri, Passmore, Lori A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615087/
https://www.ncbi.nlm.nih.gov/pubmed/37653243
http://dx.doi.org/10.1038/s41594-023-01075-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615087/
https://www.ncbi.nlm.nih.gov/pubmed/37653243
http://dx.doi.org/10.1038/s41594-023-01075-8

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