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Specific recognition and ubiquitination of translating ribosomes by mammalian CCR4-NOT
Translation impacts mRNA stability and, in yeast, this is mediated by the Ccr4-Not deadenylation complex. The details of this process in mammals remain unclear. Here, we use cryoEM and crosslinking mass spectrometry to show that mammalian CCR4-NOT specifically recognizes ribosomes that are stalled d...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615087/ https://www.ncbi.nlm.nih.gov/pubmed/37653243 http://dx.doi.org/10.1038/s41594-023-01075-8 |