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Nodal signaling establishes a competency window for stochastic cell fate switching

Specification of the germ layers by Nodal signaling has long been regarded as an archetype of how graded morphogens induce different cell fates. However, this deterministic model cannot explain why only a subset of cells at the early zebrafish embryo margin adopt the endodermal fate, whereas their i...

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Detalles Bibliográficos
Autores principales: Economou, Andrew D., Guglielmi, Luca, East, Philip, Hill, Caroline S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615190/
https://www.ncbi.nlm.nih.gov/pubmed/36473458
http://dx.doi.org/10.1016/j.devcel.2022.11.008

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