A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons

Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with persistent pain. Chemogenetics has shown promise as a means to suppress such excitability, yet chemogenetic approaches suitable for human applications are needed. PSAM(4)-GlyR is a modular syste...

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Detalles Bibliográficos
Autores principales: Perez-Sanchez, Jimena, Middleton, Steven J., Pattison, Luke A., Hilton, Helen, Awadelkareem, Mosab Ali, Zuberi, Sana R., Renke, Maria B., Hu, Huimin, Yang, Xun, Clark, Alex J., Smith, Ewan St. John, Bennett, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615191/
https://www.ncbi.nlm.nih.gov/pubmed/37792955
http://dx.doi.org/10.1126/scitranslmed.adh3839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615191/
https://www.ncbi.nlm.nih.gov/pubmed/37792955
http://dx.doi.org/10.1126/scitranslmed.adh3839

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