BCL2 inhibition reveals a dendritic cell-specific immune checkpoint that controls tumor immunosurveillance

We developed a phenotypic screening platform for the functional exploration of dendritic cells (DC). Here, we report a genome-wide CRISPR screen that revealed BCL2 as an endogenous inhibitor of DC function. Knockout of BCL2 enhanced DC antigen presentation and activation as well as the capacity of D...

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Detalles Bibliográficos
Autores principales: Zhao, Liwei, Liu, Peng, Mao, Misha, Zhang, Shuai, Bigenwald, Camille, Dutertre, Charles-Antoine, Lehmann, Christian H. K., Pan, Hui, Paulhan, Nicolas, Amon, Lukas, Buqué, Aitziber, Yamazaki, Takahiro, Galluzzi, Lorenzo, Kloeckner, Benoit, Silvin, Aymeric, Pan, Yuhong, Chen, Hui, Tian, Ai-Ling, Ly, Pierre, Dudziak, Diana, Zitvogel, Laurence, Kepp, Oliver, Kroemer, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615270/
https://www.ncbi.nlm.nih.gov/pubmed/37623817
http://dx.doi.org/10.1158/2159-8290.CD-22-1338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615270/
https://www.ncbi.nlm.nih.gov/pubmed/37623817
http://dx.doi.org/10.1158/2159-8290.CD-22-1338

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