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Desacetyl-α-MSH and α-MSH have sex specific interactions with diet to influence mouse gut morphology, metabolites and microbiota

The melanocortin peptides have an important role in regulating body weight and appetite. Mice that lack the desacetyl-α-MSH and α-MSH peptides (Pomc(tm1/tm1)) develop obesity. This effect is exacerbated by a high fat diet (HFD). However, development of obesity in female Pomc(tm1/tm1) mice during chr...

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Detalles Bibliográficos
Autores principales: Sun, Bo, Vatanen, Tommi, Jayasinghe, Thilini N., McKenzie, Elizabeth, Murphy, Rinki, O’Sullivan, Justin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641164/
https://www.ncbi.nlm.nih.gov/pubmed/33144604
http://dx.doi.org/10.1038/s41598-020-75786-z