cAMP-dependent regulation of HCN4 controls the tonic entrainment process in sinoatrial node pacemaker cells

It is highly debated how cyclic adenosine monophosphate-dependent regulation (CDR) of the major pacemaker channel HCN4 in the sinoatrial node (SAN) is involved in heart rate regulation by the autonomic nervous system. We addressed this question using a knockin mouse line expressing cyclic adenosine...

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Detalles Bibliográficos
Autores principales: Fenske, Stefanie, Hennis, Konstantin, Rötzer, René D., Brox, Verena F., Becirovic, Elvir, Scharr, Andreas, Gruner, Christian, Ziegler, Tilman, Mehlfeld, Verena, Brennan, Jaclyn, Efimov, Igor R., Pauža, Audrys G., Moser, Markus, Wotjak, Carsten T., Kupatt, Christian, Gönner, Rasmus, Zhang, Rai, Zhang, Henggui, Zong, Xiangang, Biel, Martin, Wahl-Schott, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641277/
https://www.ncbi.nlm.nih.gov/pubmed/33144559
http://dx.doi.org/10.1038/s41467-020-19304-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641277/
https://www.ncbi.nlm.nih.gov/pubmed/33144559
http://dx.doi.org/10.1038/s41467-020-19304-9

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