DSS1 and ssDNA regulate oligomerization of BRCA2

The tumor suppressor BRCA2 plays a key role in initiating homologous recombination by facilitating RAD51 filament formation on single-stranded DNA. The small acidic protein DSS1 is a crucial partner to BRCA2 in this process. In vitro and in cells (1,2), BRCA2 associates into oligomeric complexes bes...

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Detalles Bibliográficos
Autores principales: Le, Hang Phuong, Ma, Xiaoyan, Vaquero, Jorge, Brinkmeyer, Megan, Guo, Fei, Heyer, Wolf-Dietrich, Liu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641332/
https://www.ncbi.nlm.nih.gov/pubmed/32609828
http://dx.doi.org/10.1093/nar/gkaa555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641332/
https://www.ncbi.nlm.nih.gov/pubmed/32609828
http://dx.doi.org/10.1093/nar/gkaa555

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