A genetic variant controls interferon-β gene expression in human myeloid cells by preventing C/EBP-β binding on a conserved enhancer

Interferon β (IFN-β) is a cytokine that induces a global antiviral proteome, and regulates the adaptive immune response to infections and tumors. Its effects strongly depend on its level and timing of expression. Therefore, the transcription of its coding gene IFNB1 is strictly controlled. We have p...

Descripción completa

Detalles Bibliográficos
Autores principales: Assouvie, Anaïs, Rotival, Maxime, Hamroune, Juliette, Busso, Didier, Romeo, Paul-Henri, Quintana-Murci, Lluis, Rousselet, Germain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641354/
https://www.ncbi.nlm.nih.gov/pubmed/33147208
http://dx.doi.org/10.1371/journal.pgen.1009090

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641354/
https://www.ncbi.nlm.nih.gov/pubmed/33147208
http://dx.doi.org/10.1371/journal.pgen.1009090

Ejemplares similares