A GFR-Based Method to Predict the Effect of Renal Impairment on the Exposure or Clearance of Renally Excreted Drugs: A Comparative Study Between a Simple GFR Method and a Physiologically Based Pharmacokinetic Model

OBJECTIVE: The objective of this study was to compare the predictive performances of a glomerular filtration rate (GFR) model with a physiologically based pharmacokinetic (PBPK) model to predict total or renal clearance or area under the curve of renally excreted drugs in subjects with varying degre...

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Detalles Bibliográficos
Autor principal: Mahmood, Iftekhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641486/
https://www.ncbi.nlm.nih.gov/pubmed/33150526
http://dx.doi.org/10.1007/s40268-020-00327-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641486/
https://www.ncbi.nlm.nih.gov/pubmed/33150526
http://dx.doi.org/10.1007/s40268-020-00327-y

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