CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication

Mostrar otras versiones (1)

ATR functions as a master regulator of the DNA-damage response. ATR activation requires the ATR activator, topoisomerase IIβ-binding protein 1 (TopBP1). However, the underlying mechanism of TopBP1 regulation and how its regulation affects DNA replication remain unknown. Here, we report a specific in...

Descripción completa

Detalles Bibliográficos
Autores principales: Feng, Haihua, Lu, Jingchen, Song, Xiaotian, Thongkum, Angkana, Zhang, Fan, Lou, Lihong, Reizes, Ofer, Almasan, Alexandru, Gong, Zihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641741/
https://www.ncbi.nlm.nih.gov/pubmed/33010150
http://dx.doi.org/10.1093/nar/gkaa756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641741/
https://www.ncbi.nlm.nih.gov/pubmed/33010150
http://dx.doi.org/10.1093/nar/gkaa756

Ejemplares similares