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CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication

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ATR functions as a master regulator of the DNA-damage response. ATR activation requires the ATR activator, topoisomerase IIβ-binding protein 1 (TopBP1). However, the underlying mechanism of TopBP1 regulation and how its regulation affects DNA replication remain unknown. Here, we report a specific in...

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Detalles Bibliográficos
Autores principales:	Feng, Haihua, Lu, Jingchen, Song, Xiaotian, Thongkum, Angkana, Zhang, Fan, Lou, Lihong, Reizes, Ofer, Almasan, Alexandru, Gong, Zihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641741/ https://www.ncbi.nlm.nih.gov/pubmed/33010150 http://dx.doi.org/10.1093/nar/gkaa756

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