Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data

Somatic hypermutations of immunoglobulin (Ig) genes occurring during affinity maturation drive B-cell receptors’ ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. H...

Descripción completa

Detalles Bibliográficos
Autores principales: Spisak, Natanael, Walczak, Aleksandra M, Mora, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641750/
https://www.ncbi.nlm.nih.gov/pubmed/33035336
http://dx.doi.org/10.1093/nar/gkaa825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641750/
https://www.ncbi.nlm.nih.gov/pubmed/33035336
http://dx.doi.org/10.1093/nar/gkaa825

Ejemplares similares