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Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data
Somatic hypermutations of immunoglobulin (Ig) genes occurring during affinity maturation drive B-cell receptors’ ability to evolve strong binding to their antigenic targets. The landscape of these mutations is highly heterogeneous, with certain regions of the Ig gene being preferentially targeted. H...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641750/ https://www.ncbi.nlm.nih.gov/pubmed/33035336 http://dx.doi.org/10.1093/nar/gkaa825 |