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Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates
Potent knockdown of pathogenic RNA in vivo is an urgent health need unmet by both small-molecule and biologic drugs. ‘Smart’ supramolecular assembly of catalysts offers precise recognition and potent destruction of targeted RNA, hitherto not found in nature. Peptidyl-oligonucleotide ribonucleases ar...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641753/ https://www.ncbi.nlm.nih.gov/pubmed/33010175 http://dx.doi.org/10.1093/nar/gkaa780 |