Evolution of a highly functional circular DNA aptamer in serum

Circular DNA aptamers are powerful candidates for therapeutic applications given their dramatically enhanced biostability. Herein we report the first effort to evolve circular DNA aptamers that bind a human protein directly in serum, a complex biofluid. Targeting human thrombin, this strategy has le...

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Detalles Bibliográficos
Autores principales: Mao, Yu, Gu, Jimmy, Chang, Dingran, Wang, Lei, Yao, Lili, Ma, Qihui, Luo, Zhaofeng, Qu, Hao, Li, Yingfu, Zheng, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641760/
https://www.ncbi.nlm.nih.gov/pubmed/33021630
http://dx.doi.org/10.1093/nar/gkaa800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641760/
https://www.ncbi.nlm.nih.gov/pubmed/33021630
http://dx.doi.org/10.1093/nar/gkaa800

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