Cargando…
METTL3 counteracts premature aging via m(6)A-dependent stabilization of MIS12 mRNA
N(6)-Methyladenosine (m(6)A) messenger RNA methylation is a well-known epitranscriptional regulatory mechanism affecting central biological processes, but its function in human cellular senescence remains uninvestigated. Here, we found that levels of both m(6)A RNA methylation and the methyltransfer...
Autores principales: | Wu, Zeming, Shi, Yue, Lu, Mingming, Song, Moshi, Yu, Zihui, Wang, Jilu, Wang, Si, Ren, Jie, Yang, Yun-Gui, Liu, Guang-Hui, Zhang, Weiqi, Ci, Weimin, Qu, Jing |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641765/ https://www.ncbi.nlm.nih.gov/pubmed/33035345 http://dx.doi.org/10.1093/nar/gkaa816 |
Ejemplares similares
-
SUMOylation of the m(6)A-RNA methyltransferase METTL3 modulates its function
por: Du, Yuzhang, et al.
Publicado: (2018) -
SMG-6 mRNA cleavage stalls ribosomes near premature stop codons in vivo
por: Kim, John H, et al.
Publicado: (2022) -
Control of mRNA decapping by autoinhibition
por: Paquette, David R, et al.
Publicado: (2018) -
Determinants of the temperature adaptation of mRNA degradation
por: Jaquet, Vincent, et al.
Publicado: (2022) -
Dynamic m(6)A modification regulates local translation of mRNA in axons
por: Yu, Jun, et al.
Publicado: (2018)