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Chromosomal aberration arises during somatic reprogramming to pluripotent stem cells
BACKGROUND: Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) has opened new therapeutic possibilities. However, karyotypic abnormalities detected in iPSCs compromised their utility, especially chromosomal aberrations found at early passages raised serious safety concerns. The me...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641821/ https://www.ncbi.nlm.nih.gov/pubmed/33292330 http://dx.doi.org/10.1186/s13008-020-00068-z |