Truncation or Deglycosylation of the Neuraminidase Stalk Enhances the Pathogenicity of the H5N1 Subtype Avian Influenza Virus in Mallard Ducks

H5N1 subtype avian influenza virus (AIV) with a deletion of 20 amino acids at residues 49–68 in the stalk region of neuraminidase (NA) became a major epidemic virus. To determine the effect of truncation or deglycosylation of the NA stalk on virulence, we used site-directed mutagenesis to insert 20...

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Detalles Bibliográficos
Autores principales: Chen, Sujuan, Quan, Keji, Wang, Dandan, Du, Yinping, Qin, Tao, Peng, Daxin, Liu, Xiufan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641914/
https://www.ncbi.nlm.nih.gov/pubmed/33193225
http://dx.doi.org/10.3389/fmicb.2020.583588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641914/
https://www.ncbi.nlm.nih.gov/pubmed/33193225
http://dx.doi.org/10.3389/fmicb.2020.583588

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