Cargando…

Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells

AIMS/HYPOTHESIS: In islets from individuals with type 2 diabetes and in islets exposed to chronic elevated glucose, mitochondrial energy metabolism is impaired. Here, we studied early metabolic changes and mitochondrial adaptations in human beta cells during chronic glucose stress. METHODS: Respirat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chareyron, Isabelle, Christen, Stefan, Moco, Sofia, Valsesia, Armand, Lassueur, Steve, Dayon, Loïc, Wollheim, Claes B., Santo Domingo, Jaime, Wiederkehr, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641954/ https://www.ncbi.nlm.nih.gov/pubmed/32960311 http://dx.doi.org/10.1007/s00125-020-05275-5

Ejemplares similares

Glucose-dependent phosphorylation signaling pathways and crosstalk to mitochondrial respiration in insulin secreting cells
por: Santo-Domingo, Jaime, et al.
Publicado: (2019)

Linking Fatty Acid Stress to β-Cell Mitochondrial Dynamics
por: Wiederkehr, Andreas, et al.
Publicado: (2009)

Defective Mitochondrial Function and Motility Due to Mitofusin 1 Overexpression in Insulin Secreting Cells
por: Park, Kyu-Sang, et al.
Publicado: (2012)

Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation
por: Valera-Alberni, Miriam, et al.
Publicado: (2021)

Mitochondrial respiratory chain dysfunction alters ER sterol sensing and mevalonate pathway activity
por: Wall, Christopher Tadhg James, et al.
Publicado: (2022)

Mitochondrial ion channels in pancreatic β‐cells: Novel pharmacological targets for the treatment of Type 2 diabetes
por: De Marchi, Umberto, et al.
Publicado: (2020)

The renaissance of mitochondrial pH
por: Santo-Domingo, Jaime, et al.
Publicado: (2012)

Eloge de la pifométrie: du pif au mètre en passant par la belle lurette...
por: Chareyron, Luc
Publicado: (2099)

Obesity shows preserved plasma proteome in large independent clinical cohorts
por: Cominetti, Ornella, et al.
Publicado: (2018)

Analysis of 1508 Plasma Samples by Capillary-Flow Data-Independent Acquisition Profiles Proteomics of Weight Loss and Maintenance
por: Bruderer, Roland, et al.
Publicado: (2019)

Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala
por: Chareyron, Loïc J., et al.
Publicado: (2021)

Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation
por: Phelps, Edward A., et al.
Publicado: (2017)

Dynamic Regulation of the Mitochondrial Proton Gradient during Cytosolic Calcium Elevations
por: Poburko, Damon, et al.
Publicado: (2011)

2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart
por: Aiestaran-Zelaia, Irati, et al.
Publicado: (2022)

Corrigendum: Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation
por: Phelps, Edward A., et al.
Publicado: (2017)

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
por: Sambeat, Audrey, et al.
Publicado: (2019)

Normal Glucagon Signaling and β-Cell Function After Near-Total α-Cell Ablation in Adult Mice
por: Thorel, Fabrizio, et al.
Publicado: (2011)

Studying Metabolism by NMR-Based Metabolomics
por: Moco, Sofia
Publicado: (2022)

Untargeted Profiling of Bile Acids and Lysophospholipids Identifies the Lipid Signature Associated with Glycemic Outcome in an Obese Non-Diabetic Clinical Cohort
por: Christinat, Nicolas, et al.
Publicado: (2020)

The promise of multi-omics approaches to discover biological alterations with clinical relevance in Alzheimer’s disease
por: Clark, Christopher, et al.
Publicado: (2022)

Differential Contribution of Transcription Factors to Arabidopsis thaliana Defense Against Spodoptera littoralis
por: Schweizer, Fabian, et al.
Publicado: (2013)

Signalling of Arabidopsis thaliana response to Pieris brassicae eggs shares similarities with PAMP-triggered immunity
por: Gouhier-Darimont, Caroline, et al.
Publicado: (2013)

Ablation of GPR56 Causes β-Cell Dysfunction by ATP Loss through Mistargeting of Mitochondrial VDAC1 to the Plasma Membrane
por: Mohammad Al-Amily, Israa, et al.
Publicado: (2023)

GABA in the Endocrine Pancreas: Its Putative Role as an Islet Cell Paracrine-signalling Molecule
por: Franklin, Isobel K., et al.
Publicado: (2004)

Combined biotic stresses trigger similar transcriptomic responses but contrasting resistance against a chewing herbivore in Brassica nigra
por: Bonnet, Christelle, et al.
Publicado: (2017)

A Method to Monitor the NAD(+) Metabolome—From Mechanistic to Clinical Applications
por: Giner, Maria Pilar, et al.
Publicado: (2021)

Resveratrol and Its Human Metabolites—Effects on Metabolic Health and Obesity
por: Springer, Margherita, et al.
Publicado: (2019)

The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state
por: Weiser, Anna, et al.
Publicado: (2023)

An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer’s disease
por: Clark, Christopher, et al.
Publicado: (2021)

Cerebrospinal Fluid Proteome Alterations Associated with Neuropsychiatric Symptoms in Cognitive Decline and Alzheimer’s Disease
por: Mroczek, Magdalena, et al.
Publicado: (2022)

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell
por: Ofori, Jones K., et al.
Publicado: (2017)

Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma)
por: Scheja, Agneta, et al.
Publicado: (2001)

The Growing Importance of CNVs: New Insights for Detection and Clinical Interpretation
por: Valsesia, Armand, et al.
Publicado: (2013)

Exploration of human cerebrospinal fluid: A large proteome dataset revealed by trapped ion mobility time-of-flight mass spectrometry
por: Macron, Charlotte, et al.
Publicado: (2020)

Systemic and central nervous system neuroinflammatory signatures of neuropsychiatric symptoms and related cognitive decline in older people
por: Clark, Christopher, et al.
Publicado: (2022)

AssociationViewer: a scalable and integrated software tool for visualization of large-scale variation data in genomic context
por: Martin, Olivier, et al.
Publicado: (2009)

Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress
por: Xu, S, et al.
Publicado: (2015)

Muscle hypertrophic effect of inhaled beta(2)‐agonist is associated with augmented insulin‐stimulated whole‐body glucose disposal in young men
por: Jessen, Søren, et al.
Publicado: (2022)

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes
por: Ly, Luong Dai, et al.
Publicado: (2017)

Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site
por: Sanders, Matthew J., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0nmjaq17tl29u13a43jf1j9s0u