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Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors
Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical, therapeutic and pharmaceutical applications. Herein, w...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642207/ https://www.ncbi.nlm.nih.gov/pubmed/33193332 http://dx.doi.org/10.3389/fimmu.2020.565096 |
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author | Lee, Chloe H. Salio, Mariolina Napolitani, Giorgio Ogg, Graham Simmons, Alison Koohy, Hashem |
author_facet | Lee, Chloe H. Salio, Mariolina Napolitani, Giorgio Ogg, Graham Simmons, Alison Koohy, Hashem |
author_sort | Lee, Chloe H. |
collection | PubMed |
description | Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical, therapeutic and pharmaceutical applications. Herein, we review recent developments in predicting cross-reactivity and antigen specificity of TCR recognition. We discuss current experimental and computational approaches to investigate cross-reactivity and antigen-specificity of TCRs and highlight how integrating kinetic, biophysical and structural features may offer valuable insights in modeling immunogenicity. We further underscore the close inter-relationship of these two interconnected notions and the need to investigate each in the light of the other for a better understanding of T cell responsiveness for the effective clinical applications. |
format | Online Article Text |
id | pubmed-7642207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76422072020-11-13 Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors Lee, Chloe H. Salio, Mariolina Napolitani, Giorgio Ogg, Graham Simmons, Alison Koohy, Hashem Front Immunol Immunology Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical, therapeutic and pharmaceutical applications. Herein, we review recent developments in predicting cross-reactivity and antigen specificity of TCR recognition. We discuss current experimental and computational approaches to investigate cross-reactivity and antigen-specificity of TCRs and highlight how integrating kinetic, biophysical and structural features may offer valuable insights in modeling immunogenicity. We further underscore the close inter-relationship of these two interconnected notions and the need to investigate each in the light of the other for a better understanding of T cell responsiveness for the effective clinical applications. Frontiers Media S.A. 2020-10-22 /pmc/articles/PMC7642207/ /pubmed/33193332 http://dx.doi.org/10.3389/fimmu.2020.565096 Text en Copyright © 2020 Lee, Salio, Napolitani, Ogg, Simmons and Koohy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Lee, Chloe H. Salio, Mariolina Napolitani, Giorgio Ogg, Graham Simmons, Alison Koohy, Hashem Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors |
title | Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors |
title_full | Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors |
title_fullStr | Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors |
title_full_unstemmed | Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors |
title_short | Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors |
title_sort | predicting cross-reactivity and antigen specificity of t cell receptors |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642207/ https://www.ncbi.nlm.nih.gov/pubmed/33193332 http://dx.doi.org/10.3389/fimmu.2020.565096 |
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