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Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors

Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical, therapeutic and pharmaceutical applications. Herein, w...

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Autores principales: Lee, Chloe H., Salio, Mariolina, Napolitani, Giorgio, Ogg, Graham, Simmons, Alison, Koohy, Hashem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642207/
https://www.ncbi.nlm.nih.gov/pubmed/33193332
http://dx.doi.org/10.3389/fimmu.2020.565096
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author Lee, Chloe H.
Salio, Mariolina
Napolitani, Giorgio
Ogg, Graham
Simmons, Alison
Koohy, Hashem
author_facet Lee, Chloe H.
Salio, Mariolina
Napolitani, Giorgio
Ogg, Graham
Simmons, Alison
Koohy, Hashem
author_sort Lee, Chloe H.
collection PubMed
description Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical, therapeutic and pharmaceutical applications. Herein, we review recent developments in predicting cross-reactivity and antigen specificity of TCR recognition. We discuss current experimental and computational approaches to investigate cross-reactivity and antigen-specificity of TCRs and highlight how integrating kinetic, biophysical and structural features may offer valuable insights in modeling immunogenicity. We further underscore the close inter-relationship of these two interconnected notions and the need to investigate each in the light of the other for a better understanding of T cell responsiveness for the effective clinical applications.
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spelling pubmed-76422072020-11-13 Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors Lee, Chloe H. Salio, Mariolina Napolitani, Giorgio Ogg, Graham Simmons, Alison Koohy, Hashem Front Immunol Immunology Adaptive immune recognition is mediated by specific interactions between heterodimeric T cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to accurately predict TCR:pMHC interaction would have profound clinical, therapeutic and pharmaceutical applications. Herein, we review recent developments in predicting cross-reactivity and antigen specificity of TCR recognition. We discuss current experimental and computational approaches to investigate cross-reactivity and antigen-specificity of TCRs and highlight how integrating kinetic, biophysical and structural features may offer valuable insights in modeling immunogenicity. We further underscore the close inter-relationship of these two interconnected notions and the need to investigate each in the light of the other for a better understanding of T cell responsiveness for the effective clinical applications. Frontiers Media S.A. 2020-10-22 /pmc/articles/PMC7642207/ /pubmed/33193332 http://dx.doi.org/10.3389/fimmu.2020.565096 Text en Copyright © 2020 Lee, Salio, Napolitani, Ogg, Simmons and Koohy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lee, Chloe H.
Salio, Mariolina
Napolitani, Giorgio
Ogg, Graham
Simmons, Alison
Koohy, Hashem
Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors
title Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors
title_full Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors
title_fullStr Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors
title_full_unstemmed Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors
title_short Predicting Cross-Reactivity and Antigen Specificity of T Cell Receptors
title_sort predicting cross-reactivity and antigen specificity of t cell receptors
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642207/
https://www.ncbi.nlm.nih.gov/pubmed/33193332
http://dx.doi.org/10.3389/fimmu.2020.565096
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