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Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity

Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in around 10–20% of these patients is lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine...

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Autores principales: Cyrta, Joanna, Augspach, Anke, De Filippo, Maria Rosaria, Prandi, Davide, Thienger, Phillip, Benelli, Matteo, Cooley, Victoria, Bareja, Rohan, Wilkes, David, Chae, Sung-Suk, Cavaliere, Paola, Dephoure, Noah, Uldry, Anne-Christine, Lagache, Sophie Braga, Roma, Luca, Cohen, Sandra, Jaquet, Muriel, Brandt, Laura P., Alshalalfa, Mohammed, Puca, Loredana, Sboner, Andrea, Feng, Felix, Wang, Shangqian, Beltran, Himisha, Lotan, Tamara, Spahn, Martin, Kruithof-de Julio, Marianna, Chen, Yu, Ballman, Karla V., Demichelis, Francesca, Piscuoglio, Salvatore, Rubin, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642293/
https://www.ncbi.nlm.nih.gov/pubmed/33144576
http://dx.doi.org/10.1038/s41467-020-19328-1
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author Cyrta, Joanna
Augspach, Anke
De Filippo, Maria Rosaria
Prandi, Davide
Thienger, Phillip
Benelli, Matteo
Cooley, Victoria
Bareja, Rohan
Wilkes, David
Chae, Sung-Suk
Cavaliere, Paola
Dephoure, Noah
Uldry, Anne-Christine
Lagache, Sophie Braga
Roma, Luca
Cohen, Sandra
Jaquet, Muriel
Brandt, Laura P.
Alshalalfa, Mohammed
Puca, Loredana
Sboner, Andrea
Feng, Felix
Wang, Shangqian
Beltran, Himisha
Lotan, Tamara
Spahn, Martin
Kruithof-de Julio, Marianna
Chen, Yu
Ballman, Karla V.
Demichelis, Francesca
Piscuoglio, Salvatore
Rubin, Mark A.
author_facet Cyrta, Joanna
Augspach, Anke
De Filippo, Maria Rosaria
Prandi, Davide
Thienger, Phillip
Benelli, Matteo
Cooley, Victoria
Bareja, Rohan
Wilkes, David
Chae, Sung-Suk
Cavaliere, Paola
Dephoure, Noah
Uldry, Anne-Christine
Lagache, Sophie Braga
Roma, Luca
Cohen, Sandra
Jaquet, Muriel
Brandt, Laura P.
Alshalalfa, Mohammed
Puca, Loredana
Sboner, Andrea
Feng, Felix
Wang, Shangqian
Beltran, Himisha
Lotan, Tamara
Spahn, Martin
Kruithof-de Julio, Marianna
Chen, Yu
Ballman, Karla V.
Demichelis, Francesca
Piscuoglio, Salvatore
Rubin, Mark A.
author_sort Cyrta, Joanna
collection PubMed
description Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in around 10–20% of these patients is lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostate cancer (NEPC) phenotype. Here, we investigate the role of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex in NEPC. Using large patient datasets, patient-derived organoids and cancer cell lines, we identify mSWI/SNF subunits that are deregulated in NEPC and demonstrate that SMARCA4 (BRG1) overexpression is associated with aggressive disease. We also show that SWI/SNF complexes interact with different lineage-specific factors in NEPC compared to prostate adenocarcinoma. These data point to a role for mSWI/SNF complexes in therapy-related lineage plasticity, which may also be relevant for other solid tumors.
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spelling pubmed-76422932020-11-10 Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity Cyrta, Joanna Augspach, Anke De Filippo, Maria Rosaria Prandi, Davide Thienger, Phillip Benelli, Matteo Cooley, Victoria Bareja, Rohan Wilkes, David Chae, Sung-Suk Cavaliere, Paola Dephoure, Noah Uldry, Anne-Christine Lagache, Sophie Braga Roma, Luca Cohen, Sandra Jaquet, Muriel Brandt, Laura P. Alshalalfa, Mohammed Puca, Loredana Sboner, Andrea Feng, Felix Wang, Shangqian Beltran, Himisha Lotan, Tamara Spahn, Martin Kruithof-de Julio, Marianna Chen, Yu Ballman, Karla V. Demichelis, Francesca Piscuoglio, Salvatore Rubin, Mark A. Nat Commun Article Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes resistant and requires more potent therapies. One mechanism of resistance observed in around 10–20% of these patients is lineage plasticity, which manifests in a partial or complete small cell or neuroendocrine prostate cancer (NEPC) phenotype. Here, we investigate the role of the mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complex in NEPC. Using large patient datasets, patient-derived organoids and cancer cell lines, we identify mSWI/SNF subunits that are deregulated in NEPC and demonstrate that SMARCA4 (BRG1) overexpression is associated with aggressive disease. We also show that SWI/SNF complexes interact with different lineage-specific factors in NEPC compared to prostate adenocarcinoma. These data point to a role for mSWI/SNF complexes in therapy-related lineage plasticity, which may also be relevant for other solid tumors. Nature Publishing Group UK 2020-11-03 /pmc/articles/PMC7642293/ /pubmed/33144576 http://dx.doi.org/10.1038/s41467-020-19328-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Cyrta, Joanna
Augspach, Anke
De Filippo, Maria Rosaria
Prandi, Davide
Thienger, Phillip
Benelli, Matteo
Cooley, Victoria
Bareja, Rohan
Wilkes, David
Chae, Sung-Suk
Cavaliere, Paola
Dephoure, Noah
Uldry, Anne-Christine
Lagache, Sophie Braga
Roma, Luca
Cohen, Sandra
Jaquet, Muriel
Brandt, Laura P.
Alshalalfa, Mohammed
Puca, Loredana
Sboner, Andrea
Feng, Felix
Wang, Shangqian
Beltran, Himisha
Lotan, Tamara
Spahn, Martin
Kruithof-de Julio, Marianna
Chen, Yu
Ballman, Karla V.
Demichelis, Francesca
Piscuoglio, Salvatore
Rubin, Mark A.
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
title Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
title_full Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
title_fullStr Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
title_full_unstemmed Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
title_short Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
title_sort role of specialized composition of swi/snf complexes in prostate cancer lineage plasticity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642293/
https://www.ncbi.nlm.nih.gov/pubmed/33144576
http://dx.doi.org/10.1038/s41467-020-19328-1
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