Bidirectional, non-necrotizing glomerular crescents are the critical pathology in X-linked Alport syndrome mouse model harboring nonsense mutation of human COL4A5

X-linked Alport syndrome (XLAS) is a progressive kidney disease caused by genetic abnormalities of COL4A5. Lack of collagen IV α5 chain staining and “basket-weave” by electron microscopy (EM) in glomerular basement membrane (GBM) are its typical pathology. However, the causal relationship between GB...

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Detalles Bibliográficos
Autores principales: Song, Jiang Ying, Saga, Nobuyuki, Kawanishi, Kunio, Hashikami, Kentaro, Takeyama, Michiyasu, Nagata, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642296/
https://www.ncbi.nlm.nih.gov/pubmed/33144651
http://dx.doi.org/10.1038/s41598-020-76068-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642296/
https://www.ncbi.nlm.nih.gov/pubmed/33144651
http://dx.doi.org/10.1038/s41598-020-76068-4

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