A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export

Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and identify >100 genes involved in LDL-cholesterol import. We characterise C18orf8 as a core subunit of the mammalian Mon1-Ccz1 gua...

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Detalles Bibliográficos
Autores principales: van den Boomen, Dick J. H., Sienkiewicz, Agata, Berlin, Ilana, Jongsma, Marlieke L. M., van Elsland, Daphne M., Luzio, J. Paul, Neefjes, Jacques J. C., Lehner, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642327/
https://www.ncbi.nlm.nih.gov/pubmed/33144569
http://dx.doi.org/10.1038/s41467-020-19032-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642327/
https://www.ncbi.nlm.nih.gov/pubmed/33144569
http://dx.doi.org/10.1038/s41467-020-19032-0

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