Investigation of Somatic Mutations in Human Brains Targeting Genes Associated With Parkinson's Disease

Background: Somatic single nucleotide variant (SNV) mutations occur in neurons but their role in synucleinopathies is unknown. Aim: We aimed to identify disease-relevant low-level somatic SNVs in brains from sporadic patients with synucleinopathies and a monozygotic twin carrying LRRK2 G2019S, whose...

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Detalles Bibliográficos
Autores principales: Leija-Salazar, Melissa, Pittman, Alan, Mokretar, Katya, Morris, Huw, Schapira, Anthony H., Proukakis, Christos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642339/
https://www.ncbi.nlm.nih.gov/pubmed/33193015
http://dx.doi.org/10.3389/fneur.2020.570424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642339/
https://www.ncbi.nlm.nih.gov/pubmed/33193015
http://dx.doi.org/10.3389/fneur.2020.570424

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